SRJ-23 |CAS:865285-29-6 Probechem Biochemicals

Chemical Structure : SRJ-23

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SRJ-23 (SRJ23;SRJ 23)

货号: PC-70353Not For Human Use, Lab Use Only.

A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation.

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生物&药学活性

A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation; significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive; reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells; induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.

物理化学性质&存储条件

分子量	317.704
分子式	C15H9ClFN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide

参考文献

1. Hocker HJ, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10201-6.

2. Jada SR, et al. Br J Pharmacol. 2008 Nov;155(5):641-54.

3. Wong HC, et al. Cell Biol Toxicol. 2014 Oct;30(5):269-88.

SRJ-23 (SRJ23;SRJ 23)

生物&药学活性

物理化学性质&存储条件

参考文献

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SRJ-23 (SRJ23;SRJ 23)

生物&药学活性

物理化学性质&存储条件

参考文献

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