SRI 37892 |CAS:1030769-75-5 Probechem Biochemicals

Chemical Structure : SRI 37892

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SRI 37892 (SRI37892;SRI-37892)

货号: PC-60973Not For Human Use, Lab Use Only.

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.

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生物&药学活性

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.
SRI 37892 also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM.
SRI 37892 demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively.
SRI 37892 targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling.

物理化学性质&存储条件

分子量	465.531
分子式	C26H19N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1H-benzo[d]imidazol-1-yl)-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)benzamide

参考文献

1. Zhang W, et al. Oncotarget. 2017 Sep 6;8(53):91459-91470.

SRI 37892 (SRI37892;SRI-37892)

生物&药学活性

物理化学性质&存储条件

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SRI 37892 (SRI37892;SRI-37892)

生物&药学活性

物理化学性质&存储条件

参考文献

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