SRI-42667 | Tau-SH3 inhibitor | Probechem Biochemicals

Chemical Structure : SRI-42667

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SRI-42667 (SRI 42667)

货号: PC-21685Not For Human Use, Lab Use Only.

SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.

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生物&药学活性

SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
SRI-42667 prevents Aβ-induced membrane trafficking dysfunction in the MTT assay and Aβ-induced neurite degeneration in the MAP2 assay.
SRI-42667 inhibits endogenous Tau-Fyn interaction at both 3 uM and 15 uM in primary neurons, does not lower Tau or Fyn levels in neurons.
SRI-42667 binds Tau (ITC KD=11.9 uM) but not FynSH3, does not inhibit Fyn or any of the 97 kinases in the DiscoverX KINOMEscan™.
SRI-42667 is a selective Tau-SH3 interaction inhibitor, does not broadly inhibit all Tau protein-protein interactions.
SRI-42667 ameliorates Aβ-induced neurite degeneration and network hyperexcitability.

物理化学性质&存储条件

分子量	336.36
分子式	C17H16N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-N-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)acetamide

参考文献

1. Jonathan R Roth, et al. Neurotherapeutics. 2023 Dec 19;21(1):e00291.

SRI-42667 (SRI 42667)

生物&药学活性

物理化学性质&存储条件

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SRI-42667 (SRI 42667)

生物&药学活性

物理化学性质&存储条件

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