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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-SRI-41897
SRI-41897

Chemical Structure : SRI-41897

CAS No.: 1208824-23-0

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SRI-41897 (SRI41897)

货号: PC-38494Not For Human Use, Lab Use Only.

SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.
    SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).
    SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs).

    物理化学性质&存储条件

    分子量 279.247
    分子式 C13H11F2N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2,4-difluorobenzyl)-N-methyl-5-nitropyridin-2-amine

    参考文献

    1. Carolyn A Robinson, et al. Viruses. 2022 Apr 15;14(4):817.

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