SRI-41315 | eRF1 degrader | Probechem Biochemicals

Chemical Structure : SRI-41315

CAS No.: 1613509-49-1

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SRI-41315 (SRI 41315)

货号: PC-73345Not For Human Use, Lab Use Only.

SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
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生物&药学活性

SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.
SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).
SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.
SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.

物理化学性质&存储条件

分子量	357.413
分子式	C22H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-

参考文献

1. Sharma J, et al. Nat Commun. 2021 Jul 16;12(1):4358.

SRI-41315 (SRI 41315)

生物&药学活性

物理化学性质&存储条件

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SRI-41315 (SRI 41315)

生物&药学活性

物理化学性质&存储条件

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