SRI-32743 | DAT inhibitor | Probechem Biochemicals

Chemical Structure : SRI-32743

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SRI-32743 (SRI 32743)

货号: PC-49495Not For Human Use, Lab Use Only.

SRI-32743 is a novel allosteric modulator of dopamine transporter (DAT), attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter.

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生物&药学活性

SRI-32743 is a novel allosteric modulator of dopamine transporter (DAT), attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter.
SRI-32743 shares the binding residues inside the pocket of DAT with Tat binding.
SRI-32743 (50 nM) attenuated Tat-induced inhibition of [3H]DA uptake and decreased the cocaine-mediated dissociation of [3H]WIN35,428 binding in CHO cells expressing hDAT.
SRI-32743 ameliorates Tat-induced cognitive deficits and potentiation of cocaine reward.
SRI-32743 reverses HIV-1 Tat-induced increase in dopamine release in the caudate putamen of inducible Tat transgenic mice.

物理化学性质&存储条件

分子量	407.52
分子式	C26H25N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(7-methylimidazo[1,2-a]pyridin-6-yl)-N-(2-phenylbutyl)quinazolin-4-amine

参考文献

1. Davis SE, et al. J Pharmacol Exp Ther. 2022 Dec 1:JPET-AR-2022-001291.

2. Jun Zhu, et al. Neuropharmacology. 2022 Dec 1;220:109239.

SRI-32743 (SRI 32743)

生物&药学活性

物理化学性质&存储条件

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SRI-32743 (SRI 32743)

生物&药学活性

物理化学性质&存储条件

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