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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-SRI-30827
SRI-30827

Chemical Structure : SRI-30827

CAS No.: 1940117-62-3

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SRI-30827 (SRI 30827)

货号: PC-22426Not For Human Use, Lab Use Only.

SRI-30827 is a selective, allosteric modulator of dopamine transporter (DAT), inhibits DA uptake in rat synaptosomes with IC50 of 0.5 nM, counteracts Tat-induced potentiation of cocaine reward.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SRI-30827 is a selective, allosteric modulator of dopamine transporter (DAT), inhibits DA uptake in rat synaptosomes with IC50 of 0.5 nM, counteracts Tat-induced potentiation of cocaine reward.

物理化学性质&存储条件

分子量 455.57
分子式 C30H25N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2,2-diphenylethyl)-2-(7-methylimidazo[1,2-a]pyridin-6-yl)quinazolin-4-amine

参考文献

1. Sun WL, et al. Sci Rep. 2017 Jun 16;7(1):3694.

2. Hammond HR, et al. NeuroImmune Pharm Ther. 2024 Mar 25;3(1):1-6.

3. Rothman RB, et al. J Pharmacol Exp Ther. 2015;353:529–538.

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