SRC-3 inhibitor SI-12

Chemical Structure : SRC-3 inhibitor SI-12

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货号: PC-20507Not For Human Use, Lab Use Only.

SRC-3 inhibitor SI-12 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 7 nM, exhibits low hERG activity (IC50=1.13 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

SRC-3 inhibitor SI-12 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 7 nM, exhibits low hERG activity (IC50=1.13 uM).
SRC-3 inhibitor SI-12 (5–50 nM) can significantly inhibit viability, migration and invasion of breast cancer cells in vitro and repress the growth of breast cancer PDX organoids.
SRC-3 inhibitor SI-12 (10 mg/kg/day) was sufficient to repress growth of xenograft tumors derived from MDA-MB-231 and LM2 cells.
SRC-3 inhibitor SI-12 effectively inhibited progression of breast cancer lung metastasis in spontaneous and experimental metastasis mouse models developed from MDA-MB-231 and LM2 cells respectively.

物理化学性质&存储条件

分子量	319.29
分子式	C15H12F3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CN1C(N/N=C(C2=NC=C(F)C=C2)\C)=NC3=CC(F)=C(F)C=C13

参考文献

1. Li Qin, et al. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670.