SR9883 | α4β2* nAChRs enhancer | Probechem Biochemicals

Chemical Structure : SR9883

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SR9883 (SR-9883)

货号: PC-23179Not For Human Use, Lab Use Only.

SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs.

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生物&药学活性

SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs.
SR9883 shows EC50 of 0.2-0.4 uM for markedly enhancing the response on HEK cells stably expressing (α4)2(β2)2β2/α4 (α4β2*), (α4)2(β2)2α5, or (α4)2(β2)2β3 nAChRs.
SR9883 (0, 5, or 10 mg/ kg) enhances the locomotor-suppressant effects of nicotine in mice.
SR9883 enhances the reward-inhibiting effects of nicotine in mice, decreases nicotine intake in rats.

物理化学性质&存储条件

分子量	248.25
分子式	C13H8N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile

参考文献

1. Braunscheidel KM, et al. Front Mol Neurosci. 2024 Sep 5;17:1459098.

SR9883 (SR-9883)

生物&药学活性

物理化学性质&存储条件

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SR9883 (SR-9883)

生物&药学活性

物理化学性质&存储条件

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