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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-SR9243
SR9243

Chemical Structure : SR9243

CAS No.: 1613028-81-1

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SR9243 (SR-9243)

货号: PC-45108Not For Human Use, Lab Use Only.

SR9243 is a potent LXR inverse agonist that inhibits LXR activation by enhancing LXR-corepressor recruitment.

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25 mg ￥1180 In stock
50 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR9243 is a potent LXR inverse agonist that inhibits LXR activation by enhancing LXR-corepressor recruitment.
SR9243 potently reduces cancer cell viability in MTT reduction assays in prostate and lung cancer cells (IC50=15-104 nM).
SR9243 inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.

物理化学性质&存储条件

分子量 626.6241
分子式 C31H32BrNO4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-

参考文献

1. Griffett K, et al. ACS Chem Biol. 2013 Mar 15;8(3):559-67.

2. Flaveny CA, et al. Cancer Cell. 2015 Jul 13;28(1):42-56.

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