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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-SR9238
SR9238

Chemical Structure : SR9238

CAS No.: 1416153-62-2

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SR9238 (SR-9283)

货号: PC-63083Not For Human Use, Lab Use Only.

SR9238 is the first selective synthetic LXR inverse agonist with IC50 of 214 nM and 43 nM for LXRα and LXRβ, respectively.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR9238 is the first selective synthetic LXR inverse agonist with IC50 of 214 nM and 43 nM for LXRα and LXRβ, respectively.
SR9238 displays high potency for both LXRα and LXRβ (IC50=40-200 nM).
SR9238 suppresses plasma cholesterol levels in diet-induced obese mice.

物理化学性质&存储条件

分子量 595.7
分子式 C31H33NO7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate

参考文献

1. Griffett K, et al. ACS Chem Biol. 2013 Mar 15;8(3):559-67.

2. Griffett K, et al. Mol Metab. 2015 Feb 9;4(4):353-7.

3. Griffett K, et al. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.

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