SR9011 hydrochloride |CAS: 2070014-94-5 Probechem Biochemicals

Chemical Structure : SR9011 hydrochloride

CAS No.: 2070014-94-5

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SR9011 hydrochloride (SR-9011 hydrochloride)

货号: PC-45117Not For Human Use, Lab Use Only.

SR9011 hydrochloride is a potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.

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生物&药学活性

SR9011 hydrochloride is a potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.
SR9011 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (IC50=710 nM).
SR9011 decreases obesity by reducing fat mass and markedly improves dyslipidaemia and hyperglycaemia in diet-induced obese mice.

物理化学性质&存储条件

分子量	515.4962
分子式	C23H32Cl2N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	1-Pyrrolidinecarboxamide, 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-,hydrochloride

参考文献

1. Solt LA, et al. Nature. 2012 Mar 29;485(7396):62-8.

2. Banerjee S, et al. Nat Commun. 2014 Dec 23;5:5759.

3. Alibhai FJ, et al. J Mol Cell Cardiol. 2017 Apr;105:24-37.

SR9011 hydrochloride (SR-9011 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR9011 hydrochloride (SR-9011 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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