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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Rev-ErbA-SR9011
SR9011

Chemical Structure : SR9011

CAS No.: 1379686-29-9

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SR9011 (SR-9011)

货号: PC-45116Not For Human Use, Lab Use Only.

SR9011 is a potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.

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10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR9011 is a potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.
SR9011 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (IC50=710 nM).
SR9011 decreases obesity by reducing fat mass and markedly improves dyslipidaemia and hyperglycaemia in diet-induced obese mice.

物理化学性质&存储条件

分子量 479.0352
分子式 C23H31ClN4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 43 mg/mL
Chemical Name/SMILES

1-Pyrrolidinecarboxamide, 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-

参考文献

1. Solt LA, et al. Nature. 2012 Mar 29;485(7396):62-8.

2. Banerjee S, et al. Nat Commun. 2014 Dec 23;5:5759.

3. Alibhai FJ, et al. J Mol Cell Cardiol. 2017 Apr;105:24-37.

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