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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Rev-ErbA-SR 8278
SR 8278

Chemical Structure : SR 8278

CAS No.: 1254944-66-5

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SR 8278 (SR8278)

货号: PC-62691Not For Human Use, Lab Use Only.

SR 8278 is the first synthetic antagonist of the nuclear heme receptor Rev-ErbA, inhibits the REV-ERBα transcriptional repression activity with EC50 of 0.47 uM in HEK293 cells..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR 8278 is the first synthetic antagonist of the nuclear heme receptor Rev-ErbA, inhibits the REV-ERBα transcriptional repression activity with EC50 of 0.47 uM in HEK293 cells.

物理化学性质&存储条件

分子量 361.48
分子式 C18H19NO3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

参考文献

1. Kojetin D, et al. ACS Chem Biol. 2011 Feb 18;6(2):131-4.

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