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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-LIM Kinase (LIMK)-SR7826
SR7826

Chemical Structure : SR7826

CAS No.: 1219728-20-7

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SR7826 (SR 7826, SR-7826)

货号: PC-35194Not For Human Use, Lab Use Only.

SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM (LIMK1), displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).

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10 mg ￥1980 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM (LIMK1), displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).
SR7826 inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases.
SR7826 potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 <1 uM), suppresses migration and invasion of PC-3 cells in vitro.

物理化学性质&存储条件

分子量 387.43
分子式 C22H21N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-Hydroxyethyl)-N'-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-N-phenylurea

参考文献

1. Yu Q, et al. Br J Pharmacol. 2018 Jun;175(11):2077-2096.

2. Yin Y, et al. J Med Chem. 2015 Feb 26;58(4):1846-61.

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