SR2211 |CAS:1359164-11-6 Probechem Biochemicals

Chemical Structure : SR2211

CAS No.: 1359164-11-6

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SR2211 (SR-2211;SR 2211)

货号: PC-35405Not For Human Use, Lab Use Only.

SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells.

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10 mg	￥2980	In stock
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生物&药学活性

SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells.
SR2211 displays weak activity for LXRα, has no impact on the transcriptional activity of RORα and FXR.
SR2211 modulates the expression of IL 17A and IL-23R in EL-4 cells, significantly decreases IL-17A and IL-17F production in the BT co-culture system at 0.37-10 uM.
SR2211 reduces inflammatory cytokine production in LPS-stimulated RAW 264.7 cells, suppresses joint inflammation in the CIA experimental model.

物理化学性质&存储条件

分子量	527.487
分子式	C26H24F7N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol

参考文献

1. Kumar N, et al. ACS Chem Biol. 2012 Apr 20;7(4):672-7.

2. Melton AC, et al. PLoS One. 2013;8(3):e58966.

3. Chang MR, et al. Arthritis Rheumatol. 2014 Mar;66(3):579-88.

4. Wang J, et al. Nat Med. 2016 May;22(5):488-96.

SR2211 (SR-2211;SR 2211)

生物&药学活性

物理化学性质&存储条件

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SR2211 (SR-2211;SR 2211)

生物&药学活性

物理化学性质&存储条件

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