SR18662 | KLF5 inhibitor | Probechem Biochemicals

Chemical Structure : SR18662

CAS No.: 2505001-62-5

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SR18662 (SR 18662)

货号: PC-73043Not For Human Use, Lab Use Only.

SR18662 (SR 18662) is a small-molecule compound that inhibits KLF5 (IC50=4.4 nM), inhibits growth of colorectal cancer in vitro and in vivo.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

SR18662 (SR 18662) is a small-molecule compound that inhibits KLF5 (IC50=4.4 nM), inhibits growth of colorectal cancer in vitro and in vivo.
SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. SR18662 showed an increase in cells captured in either S or G2-M phases of the cell cycle and a significant increase in the number of apoptotic cells, the latter a unique property compared with ML264 or SR15006.
SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. dose-dependent inhibition of xenograft growth in mice following SR18662 treatment that exceeded the effect of ML264 at equivalent doses.

物理化学性质&存储条件

分子量	420.305
分子式	C16H19Cl2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

参考文献

1. Julie Kim, et al. Mol Cancer Ther. 2019 Nov;18(11):1973-1984.

SR18662 (SR 18662)

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SR18662 (SR 18662)

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