SR1664 | PPARγ ligand | Probechem Biochemicals

Chemical Structure : SR1664

CAS No.: 1338259-05-4

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SR1664 (SR-1664, SR 1664)

货号: PC-60333Not For Human Use, Lab Use Only.

SR1664 (SR-1664) is a potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

SR1664 (SR-1664) is a potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.
SR1664 exhibits potent anti-diabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PPARγ drugs.
SR1664 effectively improves glucose homeostasis, and does not affect bone cell mineralization in culture.

物理化学性质&存储条件

分子量	547.6
分子式	C33H29N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO
Chemical Name/SMILES	4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid

参考文献

1. Choi JH, et al. Nature. 2011 Sep 4;477(7365):477-81.

2. Choi SS, et al. J Biol Chem. 2014 Sep 19;289(38):26618-29.

3. Marciano DP, et al. Nat Commun. 2015 Jun 12;6:7443.

SR1664 (SR-1664, SR 1664)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR1664 (SR-1664, SR 1664)

生物&药学活性

物理化学性质&存储条件

参考文献

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