SR1555 | RORγ inverse agonist | Probechem Biochemicals

Chemical Structure : SR1555

CAS No.: 1386439-51-5

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SR1555 (SR 1555, SR-1555)

货号: PC-35084Not For Human Use, Lab Use Only.

SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells.

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10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
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生物&药学活性

SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells.
SR1555 is devoid of LXR, FXR, and RORα activity, displaces [3H]T0901317 from the ligand binding domain (LBD) of RORγ with IC50 of 1 uM.
SR1555 represses the expression of RORγ while leading to increased expression of FGF21 and adipoQ in pre-adipocyctes.
SR1555 inhibits activation of hormone-sensitive lipase and increased fatty acid oxidation in obese diabetic mice.

物理化学性质&存储条件

分子量	460.42
分子式	C22H22F6N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone

参考文献

1. Chang MR, et al. Mol Pharmacol. 2015 Jul;88(1):48-56.

2. Solt LA, et al. ACS Chem Biol. 2012 Sep 21;7(9):1515-9.

SR1555 (SR 1555, SR-1555)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR1555 (SR 1555, SR-1555)

生物&药学活性

物理化学性质&存储条件

参考文献

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