SR142948 hydrochloride | neurotensin receptor antagonist

Chemical Structure : SR142948 hydrochloride

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SR142948 hydrochloride (SR142948A )

货号: PC-20497Not For Human Use, Lab Use Only.

SR142948 hydrochloride is a potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM.

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生物&药学活性

SR142948 hydrochloride (SR142948A ) is a potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM.
SR142948 antagonizes neurotensin-induced inositol monophosphate formation in HT 29 cells with IC50 of 3.9 nM.
SR142948 inhibits the turning behavior induced by neurotensin in mice, completely antagonizes neurotensin-evoked acetylcholine release in the rat striatum at 0.1 mg/kg.
SR142948 also blocks both hypothermia and analgesia induced by i.c.v. injection of neurotensin injection into the ventral tegmental area.

物理化学性质&存储条件

分子量	722.32
分子式	C39H52ClN5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1(NC(C2=NN(C3=CC=C(C(N(CCCN(C)C)C)=O)C=C3C(C)C)C(C4=C(OC)C=CC=C4OC)=C2)=O)C(C5)CC6CC5CC1C6)O.[H]Cl

参考文献

1. Gully D, et al. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12.

2. Betancur C, et al. Eur J Pharmacol. 1998 Feb 5;343(1):67-77.

3. Schaeffer P, et al. J Cardiovasc Pharmacol. 1998 Apr;31(4):545-50.

SR142948 hydrochloride (SR142948A )

生物&药学活性

物理化学性质&存储条件

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SR142948 hydrochloride (SR142948A )

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物理化学性质&存储条件

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