SR12813 |CAS:126411-39-0 Probechem Biochemicals

Chemical Structure : SR12813

CAS No.: 126411-39-0

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SR12813 (SR-12813;SR 12813;GW 485801;GW-485801;GW485801)

货号: PC-42261Not For Human Use, Lab Use Only.

SR12813 (GW485801) is potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR, respectively.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

SR12813 (GW485801) is potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR, respectively.
SR12813 (GW485801) only shows weak activition for rat and mouse PXR.
SR12813 (GW485801) inhibits cholesterol synthesis (IC50=1.2 uM) with no effect on fatty acid synthesis, reduces cellular HMG-CoA reductase activity with IC50 of 0.85 uM.
SR12813 (GW485801) induce CYP3A expression in primary hepatocytes.

物理化学性质&存储条件

分子量	504.5336
分子式	C24H42O7P2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester

参考文献

1. Jones SA, et al. Mol Endocrinol. 2000 Jan;14(1):27-39.

2. Berkhout TA, et al. J Biol Chem. 1996 Jun 14;271(24):14376-82.

3. Watkins RE, et al. Science. 2001 Jun 22;292(5525):2329-33.

4. Berkhout TA, et al. Atherosclerosis. 1997 Sep;133(2):203-12.

SR12813 (SR-12813;SR 12813;GW 485801;GW-485801;GW485801)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR12813 (SR-12813;SR 12813;GW 485801;GW-485801;GW485801)

生物&药学活性

物理化学性质&存储条件

参考文献

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