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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-SR12460
SR12460

Chemical Structure : SR12460

CAS No.: 2055101-66-9

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SR12460 (SR 12460, SR-12460)

货号: PC-35770Not For Human Use, Lab Use Only.

SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM.

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5 mg ￥3580 In stock
10 mg ￥5480 In stock
25 mg ￥8580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM.
SR12460 inhibits lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO.
SR12460 suppresses LPS-induced acute pulmonary inflammation in mice without overt liver toxicity.

物理化学性质&存储条件

分子量 325.744
分子式 C15H14ClF2N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-chloropyridin-2-yl)-2-((3,5-difluorophenethyl)amino)acetamide

参考文献

1. Zhao J, et al. PLoS Biol. 2018 Jun 11;16(6):e2004663.

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