SR12343 |CAS:2055101-86-3 Probechem Biochemicals

Chemical Structure : SR12343

CAS No.: 2055101-86-3

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SR12343 (SR 12343, SR-12343)

货号: PC-35769Not For Human Use, Lab Use Only.

SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.

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5 mg	￥2280	In stock
10 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

SR12343 (SR-12343) is a novel small molecule that inhibits IKK/NF-κB activation by disrupting the association between IKKβ and NEMO.
SR12343 inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.
SR12343 acted as a NEMO-binding domain mimetic and a highly selective inhibitor of the IKK complex by disrupting the association of IKKβ and the IKKγ subunit NEMO.
SR-12343 inhibited tumor necrosis factor α (TNF-α)- and lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO and suppressed LPS-induced acute pulmonary inflammation in mice.

物理化学性质&存储条件

分子量	368.659
分子式	C15H15BrClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide

参考文献

1. Zhao J, et al. PLoS Biol. 2018 Jun 11;16(6):e2004663.
2. Zhang L, et al. Aging Cell. 2021 Dec;20(12):e13486.

SR12343 (SR 12343, SR-12343)

生物&药学活性

物理化学性质&存储条件

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SR12343 (SR 12343, SR-12343)

生物&药学活性

物理化学性质&存储条件

参考文献

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