SR1001 |CAS:1335106-03-0 Probechem Biochemicals

Chemical Structure : SR1001

CAS No.: 1335106-03-0

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SR1001 (SR-1001)

货号: PC-43525Not For Human Use, Lab Use Only.

SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity.
SR1001 inhibits the development of murine T(H)17 cells by inhibition of IL-17A gene expression and protein production, also inhibits the expression of cytokines when added to differentiated murine or human T(H)17 cells.
SR1001 modulates the expression of ROR target genes by decreasing coactivator recruitment (SRC2).
SR1001 effectively suppresses the clinical severity of autoimmune disease in mice.

物理化学性质&存储条件

分子量	477.40
分子式	C15H13F6N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 39 mg/mL
Chemical Name/SMILES	Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]-

参考文献

1. Solt LA, et al. Nature. 2011 Apr 28;472(7344):491-4.

2. Solt LA, et al. Endocrinology. 2015 Mar;156(3):869-81.

3. Beurel E, et al. Biol Psychiatry. 2013 Apr 1;73(7):622-30.

4. Ding Q, et al. BMC Immunol. 2015 May 29;16:32.

SR1001 (SR-1001)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR1001 (SR-1001)

生物&药学活性

物理化学性质&存储条件

参考文献

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