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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-SR-8993
SR-8993

Chemical Structure : SR-8993

CAS No.: 1594121-16-0

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SR-8993 (SR 8993, SR8993)

货号: PC-61596Not For Human Use, Lab Use Only.

SR-8993 is a potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SR-8993 is a potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM.
    SR-8993 dispalys a high selectivity (>100-fold) for NOP-R over the closely related opioid receptors (μ/κ/δ).
    SR-8993 prevents fear memory consolidation when injected into the central amygdala or systemically in PTSD-like model.
    SR-8993 potently reverses acute alcohol withdrawal-induced anxiety with mildly anxiolytic effect in rats.

    物理化学性质&存储条件

    分子量 412.597
    分子式 C25H37FN4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[1-(Cyclooctylmethyl)-4-piperidinyl]-5-fluoro-2-(3R)-3-pyrrolidinyl-1H-benzimidazole

    参考文献

    1. Andero R, et al. Sci Transl Med. 2013 Jun 5;5(188):188ra73.

    2. Sartor GC, et al. Brain Res. 2016 Feb 1;1632:34-41.

    3. Aziz AM, et al. Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63.

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