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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-SR-4370
SR-4370

Chemical Structure : SR-4370

CAS No.: 1816294-67-3

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SR-4370 (SR4370)

货号: PC-24027Not For Human Use, Lab Use Only.

SR-4370 is a novel HDAC inhibitor with IC50 of 0.13/0.5/0.006/3.4/2.3 μM for HDAC1/2/3/6/8, respectively, also is a latency-reversing agent (LRA) for reactivation of latent HIV-1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR-4370 is a novel HDAC inhibitor with IC50 of 0.13/0.5/0.006/3.4/2.3 μM for HDAC1/2/3/6/8, respectively, also is a latency-reversing agent (LRA) for reactivation of latent HIV-1.
SR-4370 also ameliorated dmd mutant zebrafish skeletal muscle degeneration.

物理化学性质&存储条件

分子量 304.34
分子式 C17H18F2N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2',3'-difluoro-[1,1'-biphenyl]-4-carboxylic acid, 2-butylhydrazide

参考文献

1. Zutz A, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01815-20.

2. Patent WO 2015153516 A1.

3. Louie KW, et al. bioRxiv [Preprint]. 2025 Jan 27:2025.01.24.634796.

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