SR-3677 |CAS:1072959-67-1 Probechem Biochemicals

Chemical Structure : SR-3677

CAS No.: 1072959-67-1

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SR-3677 (SR3677;SR 3677)

货号: PC-43479Not For Human Use, Lab Use Only.

SR-3677 is a potent and selective ROCK-II inhibitor with biochemical IC50 of 3 nM, inhibits myosin light chain bisphosphorylation (ppMLC) with IC50 of 3.5 nM in cell-based assays.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

SR-3677 is a potent and selective ROCK-II inhibitor with biochemical IC50 of 3 nM, inhibits myosin light chain bisphosphorylation (ppMLC) with IC50 of 3.5 nM in cell-based assays.
SR-3677 weakly inhibits ROCK-I with IC50 of 56 nM, exhibits an off-target hit rate of 1.4% against 353 kinases.
SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation.

物理化学性质&存储条件

分子量	408.45
分子式	C22H24N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 43 mg/mL
Chemical Name/SMILES	1,4-Benzodioxin-2-carboxamide, N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-

参考文献

1. Feng Y, et al. J Med Chem. 2008 Nov 13;51(21):6642-5.

SR-3677 (SR3677;SR 3677)

生物&药学活性

物理化学性质&存储条件

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SR-3677 (SR3677;SR 3677)

生物&药学活性

物理化学性质&存储条件

参考文献

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