SR-3306 |CAS:1128096-91-2 Probechem Biochemicals

Chemical Structure : SR-3306

CAS No.: 1128096-91-2

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SR-3306 (SR3306)

货号: PC-43238Not For Human Use, Lab Use Only.

SR-3306 (SR3306) is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

SR-3306 (SR3306) is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38.
SR-3306 shows cell-based IC50 of 216 nM, protects dopaminergic neurons against MPTP neurotoxicity in vitro and in vivo, achieves dopaminergic neuronal survival in the 6-OHDA model.
SR-3306 also prevents ROS increases and mitochondrial dysfunction.

物理化学性质&存储条件

分子量	490.5591
分子式	C28H26N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyrimidinamine, N-[4-[3-(6-methyl-3-pyridinyl)-1H-1,2,4-triazol-1-yl]phenyl]-4-[3-(4-morpholinyl)phenyl]-

参考文献

1. Crocker CE, et al. ACS Chem Neurosci. 2011 Apr 20;2(4):207-212.

2. Chambers JW, et al. J Biol Chem. 2013 Feb 8;288(6):4000-11.

3. Gao S, et al. Sci Rep. 2017 Feb 6;7:41795.

4. Chambers JW, et al. ACS Chem Neurosci. 2011 Apr 20;2(4):198-206.

SR-3306 (SR3306)

生物&药学活性

物理化学性质&存储条件

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SR-3306 (SR3306)

生物&药学活性

物理化学性质&存储条件

参考文献

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