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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PGC-1α-SR-18292
SR-18292

Chemical Structure : SR-18292

CAS No.: 2095432-55-4

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SR-18292 (SR18292, SR 18292)

货号: PC-62696Not For Human Use, Lab Use Only.

SR-18292 (SR18292) is a potent PGC-1α inhibitor, increases PGC-1α acetylation, suppresses gluconeogenic gene expression, and reduce glucose production in hepatocytes.

规格 价格 库存 数量
1 mg (Free Sample) ￥280 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SR-18292 (SR18292) is a potent PGC-1α inhibitor, increases PGC-1α acetylation, suppresses gluconeogenic gene expression, and reduce glucose production in hepatocytes.
SR-18292 increases the interaction of PGC-1α with GCN5 and reduces transcriptional activity of HNF4α.
SR-18292 reduces fasting blood glucose, increases hepatic insulin sensitivity, and improves glucose homeostasis in diabetic mice.

物理化学性质&存储条件

分子量 366.5
分子式 C23H30N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-2-propanol

参考文献

1. Sharabi K, et al. Cell. 2017 Mar 23;169(1):148-160.e15.

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