SR-16234 | SERM | Probechem Biochemicals

Chemical Structure : SR-16234

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SR-16234 (TAS-108, SR16234)

货号: PC-23322Not For Human Use, Lab Use Only.

SR-16234 (TAS-108) is a selective estrogen receptor modulator (SERM), blocks both the N-terminal AF-1 and C-terminal AF-2 transactivation functions.

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生物&药学活性

SR-16234 (TAS-108) is a selective estrogen receptor modulator (SERM), blocks both the N-terminal AF-1 and C-terminal AF-2 transactivation functions.
SR-16234 (TAS-108) inhibits co-activator recruitment and induce co-repressor recruitment to ERα without preventing ERα-DNA binding.
SR-16234 (TAS-108) acts as pure antagonists for the ERα (D351Y) mutant derived from a tamoxifen-resistant breast cancer cell line.

物理化学性质&存储条件

分子量	505.74
分子式	C33H47NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7S,13R,17R)-17-(2-(4-((diethylamino)methyl)-2-methoxyphenoxy)ethyl)-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

参考文献

1. Harada T, et al. Yonago Acta Med. 2018 Feb 5;60(4):227-233.

2. Yamamoto Y, et al. Clin Cancer Res. 2005 Jan 1;11(1):315-22.

SR-16234 (TAS-108, SR16234)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR-16234 (TAS-108, SR16234)

生物&药学活性

物理化学性质&存储条件

参考文献

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