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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-SQA1
SQA1

Chemical Structure : SQA1

CAS No.: 1255915-27-5

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SQA1

货号: PC-23011Not For Human Use, Lab Use Only.

SQA1 is a small molecule allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.7, also inhibits CXCR2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SQA1 is a small molecule allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.7, also inhibits CXCR2.
SQA1 binds to an intracellular pocket of CCR6.

物理化学性质&存储条件

分子量 426.47
分子式 C22H26N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Hydroxy-N,N-dimethyl-4-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-2-pyridinecarboxamide

参考文献

1. Wasilko DJ, et al. Nat Commun. 2024 Aug 31;15(1):7574.

2. Li, W. et al. J. Pharm. Exp. Ther. 386, 80–92 (2023).

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