SPX-101 |CAS:2219362-20-4 Probechem Biochemicals

Chemical Structure : SPX-101

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SPX-101 (SPX101;SPX 101)

货号: PC-63534Not For Human Use, Lab Use Only.

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits.

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生物&药学活性

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits.
SPX-101 promotes durable reduction of ENaC membrane concentration, increases mucus transport in the β-ENaC mouse model as well as the sheep model of CF.

物理化学性质&存储条件

分子量	1179.385
分子式	C53H90N14O16
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Ala-D-Ala-Leu-Pro-Ile-Pro-Leu-Asp-Gln-Thr-D-Ala-D-Ala-NH2

参考文献

1. Scott DW, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744.

2. Lennox A, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672.

SPX-101 (SPX101;SPX 101)

生物&药学活性

物理化学性质&存储条件

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SPX-101 (SPX101;SPX 101)

生物&药学活性

物理化学性质&存储条件

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