SPV106 |CAS:1036939-38-4 Probechem Biochemicals

Chemical Structure : SPV106

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SPV106 (Pentadecylidenemalonate 1b, SPV 106)

货号: PC-62267Not For Human Use, Lab Use Only.

SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP.

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生物&药学活性

SPV106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP.
SPV106 significantly increases the H3 acetylation level in U937 cells, but no detectable effect on the acetylation level of the non-histone substrate a-tubulin.
SPV106 restores normal levels of H3K9Ac and H3K14Ac, reduces DNA CpG hypermethylation, and recovers D-CMSC proliferation and differentiation.
SPV106 enhances memory for fear extinction and prevents fear renewal in mice.

物理化学性质&存储条件

分子量	310.435
分子式	C18H30O42
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pentadecylidenemalonate 1b

参考文献

1. Sbardella G, et al. Bioorg Med Chem Lett. 2008 May 1;18(9):2788-92.

2. Wei W, et al. J Neurosci. 2012 Aug 29;32(35):11930-41.

3. Vecellio M, et al. Diabetes. 2014 Jun;63(6):2132-47.

4. Castellano S, et al. ChemMedChem. 2015 Jan;10(1):144-57.

SPV106 (Pentadecylidenemalonate 1b, SPV 106)

生物&药学活性

物理化学性质&存储条件

参考文献

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SPV106 (Pentadecylidenemalonate 1b, SPV 106)

生物&药学活性

物理化学性质&存储条件

参考文献

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