SPIN1 inhibitor MS31 | SPIN1 inhibitor | Probechem Biochemicals

Chemical Structure : SPIN1 inhibitor MS31

CAS No.: 2366264-12-0

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SPIN1 inhibitor MS31 (MS31)

货号: PC-73027Not For Human Use, Lab Use Only.

SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.

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生物&药学活性

SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.
MS31 potently inhibited binding of trimethyllysine-containing peptides to SPIN1.
MS31 displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers and writers (G9a/GLP, inactive).
MS31 directly engaged SPIN1 in cells, and was not toxic to nontumorigenic cells.
MS31 selectively binds tudor domain II of SPIN1 (KD=91 nM).

物理化学性质&存储条件

分子量	341.455
分子式	C20H27N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(3-(isoindolin-2-yl)propoxy)-4-methoxy-1,3-phenylene)dimethanamine

参考文献

1. Xiong Y, et al. J Med Chem. 2019 Oct 24;62(20):8996-9007

SPIN1 inhibitor MS31 (MS31)

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物理化学性质&存储条件

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SPIN1 inhibitor MS31 (MS31)

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