SPI-21 | Spt5-Pol II inhibitor | Probechem Biochemicals

Chemical Structure : SPI-21

CAS No.: 204703-71-9

加入收藏

SPI-21 (Spt5-Pol II inhibitor 21)

货号: PC-73083Not For Human Use, Lab Use Only.

SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.

规格	价格	库存
2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5880	In stock
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.
Short-term SPI-21 treatment to HeLa cells caused a transcription upregulation (≥2-fold) of 1,371 genes, among them A20 (TNFAIP3), IL-6, IL-8 (CXCL8), and CCL20 (analyzed above), while CXCL2, IEX1 (IER3), and JUNB were unchanged.
SPI-21 precisely mimics the effect of Spt5 depletion on basal and activated NF-κB target genes and on the expanded repeat Htt gene.
Spt5 is a conserved and essential transcription elongation factor that promotes promoter-proximal pausing, promoter escape, elongation, and mRNA processing.
SPI-21 is a useful chemical probe to elucidate the function of Spt5.

物理化学性质&存储条件

分子量	270.284
分子式	C16H14O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(2,5-dihydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

参考文献

1. Bahat A, et al. Mol Cell. 2019 Nov 21;76(4):617-631.e4.

SPI-21 (Spt5-Pol II inhibitor 21)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SPI-21 (Spt5-Pol II inhibitor 21)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.