SPI-1477 | Spt5-Pol II inhibitor | Probechem Biochemicals

Chemical Structure : SPI-1477

加入收藏

SPI-1477 (SPI-77)

货号: PC-21805Not For Human Use, Lab Use Only.

SPI-1477 (SPI-77) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.1 nM, without affecting WT Htt.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SPI-1477 (SPI-77) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.1 nM, without affecting WT Htt.
SPI-1477 lowers mutant Htt protein levels in huntington's disease (HD) cells.
SPI-1477 selectively inhibits the expression of the mutant Htt gene without affecting the expression of the normal gene or other Spt5 activities.
SPI-1477 0.5 mM (0.6 µg/day) selectively reduces mutant Htt in mutant BACHD mice.
SPI-1477 attenuates HD-related behavioral phenotypes in BACHD mice, shows significant improvements in motor coordination, anxiety symptoms, and when administered to early-stage BACHD mice, slows down the progressive deterioration of the disease.

物理化学性质&存储条件

分子量	441.34
分子式	C18H14Cl2N2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,5-dichloro-2-(4-((2-(methylthio)benzyl)sulfonyl)phenyl)pyridazin-3(2H)-one

参考文献

1. Bahat A, et al. EMBO Mol Med. 2024 Feb 19. doi: 10.1038/s44321-023-00020-y.

SPI-1477 (SPI-77)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SPI-1477 (SPI-77)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.