SPHINX31 | SRPK1 inhibitor | Probechem Biochemicals

Chemical Structure : SPHINX31

CAS No.: 1818389-84-2

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SPHINX31 (SPHINX 31)

货号: PC-35908Not For Human Use, Lab Use Only.

SPHINX31 (SPHINX 31) is a potent, selective, ATP competitive inhibitor of Serine/arginine-protein kinase 1 (SRPK1) with IC50 of 5.9 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
50 mg	￥2880	In stock
100 mg		Get quote

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生物&药学活性

SPHINX31 (SPHINX 31) is a potent, selective, ATP competitive inhibitor of Serine/arginine-protein kinase 1 (SRPK1) with IC50 of 5.9 nM.
SPHINX31 displays no significant activity against other splicing modulating kinases (CLK family, DYRK1A and DYRK2, DYRK5, SRPK-2/3, PIM1, PIM2 kinases).
SPHINX31 inhibits SRPK1 mediated SRSF1 phosphorylation in PC3 prostate cancer cells with EC50 of 360 nM, dose-dependently switches splicing from VEGF-A165a to VEGF-A165b in RPE cells.
SPHINX31 potently inhibits blood vessel growth in models of choroidal angiogenesis in vivo.

物理化学性质&存储条件

分子量	507.517
分子式	C27H24F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-pyridin-4-yl-N-[2-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-5-(trifluoromethyl)phenyl]furan-2-carboxamide

参考文献

1. Batson J, et al. ACS Chem Biol. 2017 Mar 17;12(3):825-832.

2. Tzelepis K, et al. Nat Commun. 2018 Dec 19;9(1):5378.

SPHINX31 (SPHINX 31)

生物&药学活性

物理化学性质&存储条件

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SPHINX31 (SPHINX 31)

生物&药学活性

物理化学性质&存储条件

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