SPH7854 | RORγt antagonist | Probechem Biochemicals

Chemical Structure : SPH7854

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SPH7854 (SPH-7854)

货号: PC-27247Not For Human Use, Lab Use Only.

SPH7854 is a potent, selective gut-restricted RORγt antagonist with IC50 of 10 nM in RORγt binding assays, shows inhibitory activity against Th17 cell differentiation with IC50 of 34.4 nM.

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生物&药学活性

SPH7854 is a potent, selective gut-restricted RORγt antagonist with IC50 of 10 nM in RORγt binding assays, shows inhibitory activity against Th17 cell differentiation with IC50 of 34.4 nM.
SPH7854 displays excellent binding activity and selectivity for RORγ (IC50-13.7 nM) over RORα and RORβ (IC50>10000 nM).
SPH7854 effectively inhibited hPBMC Type 17 cell differentiation (IC50=147.4 nM).
SPH7854 significantly promoted the generation of Treg cells at a concentration of 3 μM and inhibited the differentiation of CD4+ inflammatory cells in rats.
SPH7854 (3mpk, bid, oral) effectively improved TNBS-induced colitis in TNBS-induced acute colitis mouse model.

物理化学性质&存储条件

分子量	451.54
分子式	C24H25N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methyl-2-(pyridin-2-yl)propanoyl)pyridin-3-yl)acetamide

参考文献

1. Zhang B, et al. Eur J Med Chem. 2026 Jun 26;317:119106.

2. Xiang Z, et al. Int Immunopharmacol. 2024 Oct 25;140:112884.

SPH7854 (SPH-7854)

生物&药学活性

物理化学性质&存储条件

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SPH7854 (SPH-7854)

生物&药学活性

物理化学性质&存储条件

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