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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-SPH5030
SPH5030

Chemical Structure : SPH5030

CAS No.: 2364326-23-6

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SPH5030 (SPH 5030)

货号: PC-72266Not For Human Use, Lab Use Only.

SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.
    SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.
    SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode.

    物理化学性质&存储条件

    分子量 582.61
    分子式 C31H31FN8O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Propenamide, N-[7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinazolinyl]-2-fluoro-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2Z)-

    参考文献

    1. Di Li, et al. Journal of Medicinal Chemistry March 23, 2022.

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