SPA8007 | BTK inhibitor | Probechem Biochemicals

Chemical Structure : SPA8007

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SPA8007 (SPA-8007)

货号: PC-25705Not For Human Use, Lab Use Only.

SPA8007 is a novel potent BTK inhibitor, shows cytotoxic effects in tumorspheres (TSs) with IC50 of 9.7 and 10 uM in normal human astrocyte and GBM TS13-64, significantly reduce the stemness and invasive properties of GBM TSs.

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生物&药学活性

SPA8007 is a novel potent BTK inhibitor, shows cytotoxic effects on GBM tumorspheres (TSs) with IC50 of 9.7 and 10 uM in normal human astrocyte and GBM TS13-64, significantly reduce the stemness and invasive properties of GBM TSs.
SPA8007 suppresses proliferation, stemness and invasiveness of GBM TSs.
SPA8007 significantly improves survival in an orthotopic mouse xenograft model.

物理化学性质&存储条件

分子量	493.56
分子式	C30H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((6-amino-5-(6-(benzyloxy)-3,4-dihydroisoquinolin-2(1H)-yl)pyridin-3-yl)oxy)phenyl acrylate

参考文献

1. Euna Jo, et al. Transl Oncol. 2025 Oct 26:63:102585.

SPA8007 (SPA-8007)

生物&药学活性

物理化学性质&存储条件

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SPA8007 (SPA-8007)

生物&药学活性

物理化学性质&存储条件

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