SPA70 | PXR antagonist | Probechem Biochemicals

Chemical Structure : SPA70

CAS No.: 931314-31-7

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SPA70 (PXR antagonist SPA70)

货号: PC-62523Not For Human Use, Lab Use Only.

SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells.
SPA70 displays highly selectivity over 10 other nuclear receptors (FXR, LXR, RXR, PPAR, etc.).
SPA70 antagonizes hPXR target genes induced by various hPXR agonists, blocks hPXR-mediated drug metabolism in vivo.

物理化学性质&存储条件

分子量	415.508
分子式	C21H25N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-(tert-butyl)phenyl)sulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole

参考文献

1. Lin W, et al. Nat Commun. 2017 Sep 29;8(1):741.

SPA70 (PXR antagonist SPA70)

生物&药学活性

物理化学性质&存储条件

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SPA70 (PXR antagonist SPA70)

生物&药学活性

物理化学性质&存储条件

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