SP 141 |CAS:1253491-42-7 Probechem Biochemicals

Chemical Structure : SP 141

CAS No.: 1253491-42-7

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SP 141 (SP-141;SP141)

货号: PC-60462Not For Human Use, Lab Use Only.

A novel specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

SP 141 is a specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation.
SP 141 induces pancreatic cancer cell death (IC50=0.38-0.5 uM) and inhibits MDM2 expression, regardless of the p53 status of the cells.
SP 141 inhibits growth of xenograft tumors in vivo.

物理化学性质&存储条件

分子量	324.383
分子式	C22H16N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole

参考文献

1. Wang W, et al. Gastroenterology. 2014 Oct;147(4):893-902.e2.

2. Qin JJ, et al. J Control Release. 2016 Sep 10;237:101-14.

SP 141 (SP-141;SP141)

生物&药学活性

物理化学性质&存储条件

参考文献

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SP 141 (SP-141;SP141)

生物&药学活性

物理化学性质&存储条件

参考文献

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