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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-SP108
SP108

Chemical Structure : SP108

CAS No.: 3024676-72-7

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SP108 (SP-108)

货号: PC-26710Not For Human Use, Lab Use Only.

SP108 is a potent, selective and brain-permeable HDAC3 inhibitor with IC50 of 15.41 nM, shows 18.72-, 34.65-, >100-, >1000-, >1000-, and >1000-fold selectivity over HDAC1, HDAC2, HDAC8, HDAC6, HDAC4, and HDAC5, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SP108 is a potent, selective and brain-permeable HDAC3 inhibitor with IC50 of 15.41 nM, shows 18.72-, 34.65-, >100-, >1000-, >1000-, and >1000-fold selectivity over HDAC1, HDAC2, HDAC8, HDAC6, HDAC4, and HDAC5, respectively.
SP108 treatment improved psychostimulant-induced hyperlocomotion and learning in MAM-exposed rodents.
SP108 treatment in MAM-induced psychotic rats increased acetylated histone levels in the hippocampus.
SP108 treatment in MAM-induced psychotic rats increased levels of memory markers in the hippocampus.

物理化学性质&存储条件

分子量 269.35
分子式 C16H19N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(phenylamino)-N'-propylbenzohydrazide

参考文献

1. Ghosh A, et al. Neuropharmacology. 2026 Apr 30;295:110999.

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