SP-8008 (PCA-8008)

Chemical Structure : SP-8008

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货号: PC-47038Not For Human Use, Lab Use Only.

SP-8008 (PCA-8008) is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.

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生物&药学活性

SP-8008 (PCA-8008) is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.
SP‐8008 binds to von Willebrand factor (vWF) at the protein-protein interaction site and inhibits the binding of GP Ib through electrostatic and steric repulsion.
SP‐8008 selectively inhibited platelet aggregation under high shear stress conditions.
SP‐8008 (5-25 mg/kg, oral) exhibited highly potent antiplatelet and antithrombotic effects by selectively attenuating platelet activation and aggregation, induced by shear stress in vivo.

物理化学性质&存储条件

分子量	288.299
分子式	C16H16O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-ethyl-3-(2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl)-4H-pyran-4-one

参考文献

1. Thien Ngo, et al. Br J Pharmacol. 2020 Feb;177(4):929-944.

SP-8008 (PCA-8008)

生物&药学活性

物理化学性质&存储条件

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SP-8008 (PCA-8008)

生物&药学活性

物理化学性质&存储条件

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