SOX18 inhibitor Sm4

Chemical Structure : SOX18 inhibitor Sm4

CAS No.: 365542-77-4

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货号: PC-38828Not For Human Use, Lab Use Only.

SOX18 inhibitor Sm4 is a specific, orally active transcription factor SOX18 inhibitor, inhibits SOX18-DNA binding and SOX18-dependent transactivation, directly disrupts SOX18 interaction with a subset of binding partners.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SOX18 inhibitor Sm4 is a specific, orally active transcription factor SOX18 inhibitor, inhibits SOX18-DNA binding and SOX18-dependent transactivation, directly disrupts SOX18 interaction with a subset of binding partners.
Sm4 disrupts the DNA-binding activity of a wide range of HMG boxes from various SOX proteins when used at high concentration (200-300 uM).
Sm4 disrupts SOX18-RBPJ interaction with IC50 of 42.3 uM, has has no effect on SOX18-MEF2C interaction.
Sm4 (25 mg/kg) suppresses vessel formation in a murine model of infantile hemangioma (IH).

物理化学性质&存储条件

分子量	292.334
分子式	C19H16O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-6-(2-(naphthalen-2-yl)ethyl)benzoic acid

参考文献

1. Frank Fontaine, et al. Cell Chem Biol. 2017 Mar 16;24(3):346-359.

2. Caroline T Seebauer, et al. J Clin Invest. 2022 Feb 1;132(3):e151109.