SOR-C13 TFA

Chemical Structure : SOR-C13 TFA

CAS No.: 1187852-48-7 (free acid)

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货号: PC-22127Not For Human Use, Lab Use Only.

SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity, selective TRPV6 calcium channel inhibitor with IC50 of 14 nM.

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5 mg	￥1580	In stock
10 mg	￥2580	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity, selective TRPV6 calcium channel inhibitor with IC50 of 14 nM.
SOR-C13 binds to TRPV6 in ovarian cancer cells with high affinity.
SOR-C13 inhibit calcium influx in TRPV6 over-expressing cells and is more effective at reducing cell viability than cis-Platin.
SOR-C13 (400, 600 and 800 mg/kg, daily i.p.) over 12 days significantly reduces ovarian tumour growth in NOD/SCID mice bearing xenografted ovarian tumours.

物理化学性质&存储条件

分子量	1565.81 (free acid)
分子式	C72H116N20O19.xC2HF3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Lys-Glu-Phe-Leu-His-Pro-Ser-Lys-Val-Asp-Leu-Pro-Arg

参考文献

1. Bowen CV, et al. PLoS One. 2013;8(3):e58866.

2. Xue H, et al. J Cancer. 2018 Aug 6;9(17):3196-3207.

SOR-C13 TFA

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物理化学性质&存储条件

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SOR-C13 TFA

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