SOMG-833 |CAS:1268264-10-3 Probechem Biochemicals

Chemical Structure : SOMG-833

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SOMG-833 (Zgwatinib, SOMG833)

货号: PC-60656Not For Human Use, Lab Use Only.

SOMG833 (Zgwatinib) is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.

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生物&药学活性

SOMG833 (Zgwatinib) is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.
SOMG833 displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL.
SOMG833 significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest.
SOMG833 demonstrates remarkable antitumor efficacy in vivo.

物理化学性质&存储条件

分子量	445.446
分子式	C22H22F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-methylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl) quinoline

参考文献

1. Zhang HT, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45.

SOMG-833 (Zgwatinib, SOMG833)

生物&药学活性

物理化学性质&存储条件

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SOMG-833 (Zgwatinib, SOMG833)

生物&药学活性

物理化学性质&存储条件

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