SOMCL-286 | FGFR/VEGFR inhibitor | Probechem Biochemicals

Chemical Structure : SOMCL-286

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SOMCL-286 (SOMCL286 )

货号: PC-26356Not For Human Use, Lab Use Only.

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生物&药学活性

SOMCL-286 (Compound 25a) is a highly potent dual FGFR/VEGFR inhibitor with IC50 of 1.0 nM against FGFR1, shows nearly equally high potency against FGFR1, FGFR2 and VEGFR-2 with IC50 values of 1.0, 4.5 and 2.9 nM, respectively.
SOMCL-286 has <0.5 nM against the FGFR1-positive KG-1cancer cell.
SOMCL-286 inhibited the proliferation of BAF3/VEGFR2 cell lines with an IC50 less than 1.5 nM.
SOMCL-286 demonstrated greater antiproliferative effects in all these FGFR1-3 subtype-selective cell lines than AZD4547, including FGFR1-amplified H1581 cells, FGFR1-translocated KG1 cells, FGFR2-amplified SNU-16 cells, FGFR3-amplified RT112 cells and FGFR3-mutated UMUC14 cells.
SOMCL-286 suppressed tumor growth in a dose-dependent manner, with tumor growth inhibition rate (TGI) of 25.0% and 81.0% at doses of 10 mg/kg and 50 mg/kg (i.p.), respectively, in SNU-16 xenograft models.

物理化学性质&存储条件

分子量	495.58
分子式	C29H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-6-((2-(4-(4-methylpiperazin-1-yl)benzamido)pyridin-4-yl)oxy)-1-naphthamide

参考文献

1. Manman Wei, et al. Eur J Med Chem. 2018 Jun 25:154:9-28.

SOMCL-286 (SOMCL286 )

生物&药学活性

物理化学性质&存储条件

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SOMCL-286 (SOMCL286 )

生物&药学活性

物理化学性质&存储条件

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