SOMCL-17-016 | BTK inhibitor | Probechem Biochemicals

Chemical Structure : SOMCL-17-016

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SOMCL-17-016 (S-016, S016)

货号: PC-22487Not For Human Use, Lab Use Only.

SOMCL-17-016 (S-016) is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 0.5 nM.

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生物&药学活性

SOMCL-17-016 (S-016) is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 0.5 nM.
S-016 displays superior kinase selectivity compared to ibrutinib and significant therapeutic effects against B-cell lymphoma both in vitro and in vivo.
S-016 inhibits the proliferation and induces G0/G1 phase arrest and apoptosis in B-cell lymphoma cells.
S-016 displays remarkable anti-proliferative activity with IC50 values of 0.55 nM and 0.70 nM against OCI-LY10 and TMD8 cell lines, respectively.
S-016 (7.5 -30 mg/kg, oral) leads to effective tumor shrinkage in OCI-LY10/TMD8 xenograft models.

物理化学性质&存储条件

分子量	463.50
分子式	C26H21N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(4-amino-7-(but-2-ynamido)-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-5-yl)-N-(pyridin-2-yl)benzamide

参考文献

1. Song PR, et al. Acta Pharmacol Sin. 2024 Jun 4. doi: 10.1038/s41401-024-01311-x.

SOMCL-17-016 (S-016, S016)

生物&药学活性

物理化学性质&存储条件

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SOMCL-17-016 (S-016, S016)

生物&药学活性

物理化学性质&存储条件

参考文献

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