SOD3 inducer BNTA | SOD3 inducer | Probechem Biochemicals

Chemical Structure : SOD3 inducer BNTA

CAS No.: 685119-25-9

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SOD3 inducer BNTA (BNTA)

货号: PC-72968Not For Human Use, Lab Use Only.

SOD3 inducer BNTA (BNTA) is a small molecule with ECM modulatory properties with target of Superoxide dismutase 3 (SOD3), a strong chondrogenic inducer that increased anabolism of chondrocytes in vitro.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SOD3 inducer BNTA (BNTA) is a small molecule with ECM modulatory properties with target of Superoxide dismutase 3 (SOD3), a strong chondrogenic inducer that increased anabolism of chondrocytes in vitro.
In human OA chondrocytes, upregulation of the expression levels of ECM-related genes COL2A1, ACAN, proteoglycan 4 (PRG4), and SRY-box 9 (SOX9) was observed upon BNTA treatment (0.01-10 uM).
BNTA upregulated ECM-related genes, remarkably increased the COL2A1 and SOX9 protein levels.
BNTA could increase Col2a1, Acan, Prg4, and Sox9 mRNA levels, with maximum effects around 0.1 uM in rat chondrocytes.
BNTA attenuated post-traumatic osteoarthritis development after intra-articular injection, attenuated post-traumatic rat osteoarthritis development.
BNTA significantly increased IL1β-reduced extracellular and intracellular SOD activities in rat primary chondrocytes.
SOD3 inducer BNTA is a promising potential for OA alleviation by modulating cartilage generation.

物理化学性质&存储条件

分子量	456.753
分子式	C17H11BrClNO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-bromo-4-(phenylsulfonyl)thiophen-3-yl)-2-chlorobenzamide

参考文献

1. Yuanyuan Shi, et al. Nat Commun. 2019 Apr 23;10(1):1914.

SOD3 inducer BNTA (BNTA)

生物&药学活性

物理化学性质&存储条件

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SOD3 inducer BNTA (BNTA)

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物理化学性质&存储条件

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